The Champigneulles brewery was founded on June 20, 1897 by Antoine Trampitsch and Victor Hinzelin under the name of Grande brasserie de la Moselle de Champigneulles-Nancy. It became the Grande brasserie de Champigneulles-Nancy in 1910 then the Grandes brasseries et malteries de Champigneulles in 1912.
In 1966, it merged with the Brasseries de la Meuse and the Brasserie de Charmes to create the Société européenne de brasserie (S.E.B). Within this new group, which has 23 production sites in France for a production of 6 million hectoliters, Champigneulles has long been the most important site. The brewery remained a family establishment until 1970, when the S.E.B was taken over by the BSN group. In 1986, S.E.B merged with Kronenbourg, also acquired by the BSN group.

Danone (formerly BSN) sold Brasseries Kronenbourg to the Scottish group Scottish & Newcastle in 2000. In 2006, Brasseries Kronenbourg and Scottish & Newcastle sold the Champigneulles brewery to the German group TCB.