The Joseph Schlitz Brewing Company was an American brewery based in Milwaukee, Wisconsin, and once the largest producer of beer in the United States. Its namesake beer, Schlitz ( /ˈʃlɪts/), was known as "The beer that made Milwaukee famous" and was advertised with the slogan "When you're out of Schlitz, you're out of beer". Schlitz first became the largest beer producer in the US in 1902 and enjoyed that status at several points during the first half of the 20th century, exchanging the title with Anheuser-Busch multiple times during the 1950s.

The company was founded by August Krug in 1849, but ownership passed to Joseph Schlitz in 1858 when he married Krug's widow. Schlitz was bought by Stroh Brewery Company in 1982 and subsequently sold along with the rest of Stroh's assets to Pabst Brewing Company in 1999. Pabst produced several varieties of Schlitz beers alongside Old Milwaukee.

Admin Note: Old Milwaukee was originally a Schlitz brand but Pabst has broken it off into its own separate brand.